Epb41l3^tm1Bhat
Targeted Allele Detail

Summary

• Symbol: Epb41l3^tm1Bhat
• Name: erythrocyte membrane protein band 4.1 like 3; targeted mutation 1, Manzoor A Bhat
• MGI ID: MGI:5140703
• Synonyms: 4.1B^Flox
• Gene: Epb41l3 Location: Chr17:69382678-69596984 bp, + strand Genetic Position: Chr17, 40.15 cM
• Alliance: Epb41l3^tm1Bhat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173383
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and a loxP site were inserted in intron 5. A second loxP site was inserted in intron 6. Exon 6 which encodes part of theFERM domain is thus flanked by loxP sites. Both 145 and 125 kDa protein isoforms were lost as a result of conditional cre expression to excise exon 6 (as determined by immunoblotting.) (J:173383)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epb41l3 Mutation: 46 strains or lines available

References

• Original: J:173383 Buttermore ED, et al., The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J Neurosci. 2011 Jun 1;31(22):8013-8024
• All: 2 reference(s)