About   Help   FAQ
Epb41l3tm1.1Bhat
Targeted Allele Detail
Summary
Symbol: Epb41l3tm1.1Bhat
Name: erythrocyte membrane protein band 4.1 like 3; targeted mutation 1.1, Manzoor A Bhat
MGI ID: MGI:5140704
Gene: Epb41l3  Location: Chr17:69382678-69596984 bp, + strand  Genetic Position: Chr17, 40.15 cM
Alliance: Epb41l3tm1.1Bhat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173383
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn FRT flanked neo cassette and a loxP site were inserted in intron 5. A second loxP site was inserted in intron 6. Exon 6 which encodes part of theFERM domain is thus flanked by loxP sites. Deletion of exon 6 by cre mediated excision also results in a frame shift creating a stop codon in exon 7. Both 145 and 125 kDa protein isoforms were lost as determined by immunoblotting. (J:173383)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epb41l3 Mutation:  46 strains or lines available
References
Original:  J:173383 Buttermore ED, et al., The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J Neurosci. 2011 Jun 1;31(22):8013-8024
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory