Epb41l3tm1.1Bhat
Targeted Allele Detail
|
Symbol: |
Epb41l3tm1.1Bhat |
Name: |
erythrocyte membrane protein band 4.1 like 3; targeted mutation 1.1, Manzoor A Bhat |
MGI ID: |
MGI:5140704 |
Gene: |
Epb41l3 Location: Chr17:69382678-69596984 bp, + strand Genetic Position: Chr17, 40.15 cM
|
Alliance: |
Epb41l3tm1.1Bhat page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:173383
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
Not Specified
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutations: |
|
Insertion, Intragenic deletion
|
|
|
Mutation details: An FRT flanked neo cassette and a loxP site were inserted in intron 5. A second loxP site was inserted in intron 6. Exon 6 which encodes part of theFERM domain is thus flanked by loxP sites. Deletion of exon 6 by cre mediated excision also results in a frame shift creating a stop codon in exon 7. Both 145 and 125 kDa protein isoforms were lost as determined by immunoblotting.
(J:173383)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Epb41l3 Mutation: |
46 strains or lines available
|
|
Original: |
J:173383 Buttermore ED, et al., The Cytoskeletal Adaptor Protein Band 4.1B Is Required for the Maintenance of Paranodal Axoglial Septate Junctions in Myelinated Axons. J Neurosci. 2011 Jun 1;31(22):8013-8024 |
All: |
2 reference(s) |
|