F2^tm2Jld
Targeted Allele Detail

Summary

• Symbol: F2^tm2Jld
• Name: coagulation factor II; targeted mutation 2, Jay L Degen
• MGI ID: MGI:5140722
• Synonyms: fII^WE
• Gene: F2 Location: Chr2:91455665-91466759 bp, - strand Genetic Position: Chr2, 50.63 cM
• Alliance: F2^tm2Jld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174629
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 14 was replaced with a modified exon 14 in which nucleotide substitutions result in the amino acid substitutions of alanine for tryptophan and glutamic acid at positions 215 and 217, respectively (W215A, E217A). An Hprt gene was inserted downstream of the modified exon. (J:174629)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2 Mutation: 36 strains or lines available

References

• Original: J:174629 Flick MJ, et al., The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011 Jun 9;117(23):6326-37
• All: 1 reference(s)