Bcl6^tm1.1Toka
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm1.1Toka
• Name: B cell leukemia/lymphoma 6; targeted mutation 1.1, Takaharu Okada
• MGI ID: MGI:5140802
• Synonyms: Bcl6^yfp, YFP-BCL6
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm1.1Toka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174014
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A monomeric EYFP gene was inserted into exon 1 and a floxed neo cassette was inserted upstream of exon 1. Cre-mediated recombination removed the neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:174014)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 57 strains or lines available

References

• Original: J:174014 Kitano M, et al., Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity. 2011 Jun 24;34(6):961-72
• All: 13 reference(s)