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Gna12tm1.1Cgh
Targeted Allele Detail
Summary
Symbol: Gna12tm1.1Cgh
Name: guanine nucleotide binding protein, alpha 12; targeted mutation 1.1, Shaun R Coughlin
MGI ID: MGI:5140818
Synonyms: Gna12-lacZ
Gene: Gna12  Location: Chr5:140745699-140816186 bp, - strand  Genetic Position: Chr5, 79.3 cM
Alliance: Gna12tm1.1Cgh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174313
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsLacZ with an SV40 polyadenylation sequence and a floxed neo cassette were inserted inframe with the first coding 51 base pairs of exon 1. Cre-mediated recombination removed the neo cassette. (J:174313)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gna12 Mutation:  23 strains or lines available
References
Original:  J:174313 Green JA, et al., The sphingosine 1-phosphate receptor S1P maintains the homeostasis of germinal center B cells and promotes niche confinement. Nat Immunol. 2011;12(7):672-80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory