Trp63^tm1Sin
Targeted Allele Detail

Summary

• Symbol: Trp63^tm1Sin
• Name: transformation related protein 63; targeted mutation 1, Satrajit Sinha
• MGI ID: MGI:5140823
• Synonyms: deltaNp63^GFP
• Gene: Trp63 Location: Chr16:25502513-25710842 bp, + strand Genetic Position: Chr16, 17.37 cM
• Alliance: Trp63^tm1Sin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173538
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP gene was fused in frame to the codon specific for the delta N isoform and an FRT flanked neo cassette was inserted via homologous recombination. Homozygous mice do not express the deltaN isoform but retain expression of the TA isoform. GFP expression mirrors that of the endogenous protein. (J:173538, J:181275)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp63 Mutation: 60 strains or lines available

References

• Original: J:173538 Packard A, et al., {Delta}Np63 regulates stem cell dynamics in the Mammalian olfactory epithelium. J Neurosci. 2011 Jun 15;31(24):8748-59
• All: 12 reference(s)