Snrpn^tm2.1Kaj
Targeted Allele Detail

Summary

• Symbol: Snrpn^tm2.1Kaj
• Name: small nuclear ribonucleoprotein N; targeted mutation 2.1, Karen A Johnstone
• MGI ID: MGI:5140864
• Synonyms: PWS-IC^flox6kb
• Gene: Snrpn Location: Chr7:59632243-59789967 bp, - strand Genetic Position: Chr7, 34.04 cM
• Alliance: Snrpn^tm2.1Kaj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174457
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted 3.7 kb upstream of exon 1. A floxed neo cassette was inserted downstream of exon 1. Cre-mediated recombination first removed the neo cassette and left the 6 kb encompassing the Prader-Willi syndrome imprinting center (PWS-IC) floxed. (J:174457)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snrpn Mutation: 23 strains or lines available

References

• Original: J:174457 Dubose AJ, et al., A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center. Hum Mol Genet. 2011 Sep 1;20(17):3461-6
• All: 3 reference(s)