Pdgfrb^{tm14(Pdgfrb)Sor}
Targeted Allele Detail

Summary

• Symbol: Pdgfrb^{tm14(Pdgfrb)Sor}
• Name: platelet derived growth factor receptor, beta polypeptide; targeted mutation 14, Philippe Soriano
• MGI ID: MGI:5140883
• Synonyms: PDGFRbeta^(S)K
• Gene: Pdgfrb Location: Chr18:61178222-61218133 bp, + strand Genetic Position: Chr18, 34.41 cM
• Alliance: Pdgfrb^{tm14(Pdgfrb)Sor} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173602
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a splice acceptor, floxed neo/stop cassette, and the mouse cDNA with nucleotide substitution(s) that results in the amino acid substitution of valine for aspartic acid at position 849 (D849V). This mutation is an activating mutation. (J:173602)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pdgfrb Mutation: 87 strains or lines available

References

• Original: J:173602 Olson LE, et al., PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development. Dev Cell. 2011 Jun 14;20(6):815-26
• All: 8 reference(s)