Nlrx1^tm1Jpyt
Targeted Allele Detail

Summary

• Symbol: Nlrx1^tm1Jpyt
• Name: NLR family member X1; targeted mutation 1, Jenny P Y Ting
• MGI ID: MGI:5141085
• Gene: Nlrx1 Location: Chr9:44164014-44179896 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Nlrx1^tm1Jpyt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173995
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on fibroblasts. (J:173995)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrx1 Mutation: 37 strains or lines available

References

• Original: J:173995 Allen IC, et al., NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-kappaB Signaling Pathways. Immunity. 2011 Jun 24;34(6):854-65
• All: 18 reference(s)