Col12a1^tm1Debi
Targeted Allele Detail

Summary

• Symbol: Col12a1^tm1Debi
• Name: collagen, type XII, alpha 1; targeted mutation 1, David E Birk
• MGI ID: MGI:5141135
• Gene: Col12a1 Location: Chr9:79506273-79626113 bp, - strand Genetic Position: Chr9, 43.82 cM
• Alliance: Col12a1^tm1Debi page

Kyphosis in 5 month old Col12a1^tm1Debi/Col12a1^tm1Debi mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174217
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: Exon 2 through exon 5 were replaced with a floxed PGK-neo selection cassette. Immunoblot analysis indicated that type XII collagen expression was completely absent. (J:174217)

Generation of the Col12a1^tm1Debi allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col12a1 Mutation: 177 strains or lines available

References

• Original: J:174217 Izu Y, et al., Type XII collagen regulates osteoblast polarity and communication during bone formation. J Cell Biol. 2011 Jun 13;193(6):1115-30
• All: 10 reference(s)