Tet2^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Tet2^tm1Ics
• Name: tet methylcytosine dioxygenase 2; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:5141225
• Synonyms: Tet2^Lox
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174052
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 11, which encodes the last 490 C-terminal amino acids, was floxed. (J:174052)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 779 strains or lines available

References

• Original: J:174052 Quivoron C, et al., TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis. Cancer Cell. 2011 Jul 12;20(1):25-38
• All: 9 reference(s)