Gata4^tm1.1Jmol
Targeted Allele Detail

Summary

• Symbol: Gata4^tm1.1Jmol
• Name: GATA binding protein 4; targeted mutation 1.1, Jeffery D Molkentin
• MGI ID: MGI:5141274
• Synonyms: Gata4-S105A, S105A
• Gene: Gata4 Location: Chr14:63436371-63509141 bp, - strand Genetic Position: Chr14, 33.24 cM
• Alliance: Gata4^tm1.1Jmol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174537
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Point mutations were introduced to change serine 105 into alanine and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of S105 phosphorylated protein and presence of non-phosphorylated protein. (J:174537)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gata4 Mutation: 36 strains or lines available

References

• Original: J:174537 van Berlo JH, et al., Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12331-6
• All: 2 reference(s)