Nfasc^tm1.2Brp
Targeted Allele Detail

Summary

• Symbol: Nfasc^tm1.2Brp
• Name: neurofascin; targeted mutation 1.2, Peter J Brophy
• MGI ID: MGI:5141294
• Synonyms: Nfasc^flox
• Gene: Nfasc Location: Chr1:132492428-132669535 bp, - strand Genetic Position: Chr1, 57.42 cM
• Alliance: Nfasc^tm1.2Brp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174740
• Parent Cell Line: E14TG2aIV (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Cre-mediated recombination of Nfasc^tm1.1Brp removed the neo cassette and left exon 4 floxed. (J:174740)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfasc Mutation: 61 strains or lines available

References

• Original: J:174740 Zonta B, et al., A critical role for Neurofascin in regulating action potential initiation through maintenance of the axon initial segment. Neuron. 2011 Mar 10;69(5):945-56
• All: 5 reference(s)