Cav1^tm1.1Aia
Targeted Allele Detail

Summary

• Symbol: Cav1^tm1.1Aia
• Name: caveolin 1, caveolae protein; targeted mutation 1.1, Alexander I Agoulnik
• MGI ID: MGI:5141474
• Gene: Cav1 Location: Chr6:17306387-17341323 bp, + strand Genetic Position: Chr6, 7.73 cM, cytoband A2
• Alliance: Cav1^tm1.1Aia page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174719
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the neo cassette. Immunohistochemistry confirmed the absence of protein expression in the uterus. (J:174719)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cav1 Mutation: 31 strains or lines available

References

• Original: J:174719 Li Z, et al., Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2. Endocrinology. 2011 Jun;152(6):2474-82
• All: 1 reference(s)