Tg(Rxfp2-cre)#Aia
Transgene Detail

Summary

• Symbol: Tg(Rxfp2-cre)#Aia
• Name: transgene insertion, Alexander I Agoulnik
• MGI ID: MGI:5141475
• Synonyms: Rxfp2-icre
• Transgene: Tg(Rxfp2-cre)#Aia Location: unknown
• Alliance: Tg(Rxfp2-cre)#Aia page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Rxfp2-cre)#Aia expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Rxfp2

• Mutation details: The transgene comprises the 2429 base pairs that reside immediately upstream of the translation initiation codon of the relaxin/insulin-like family peptide receptor 2 gene, a 1.1-kb DNA fragment containing a consensus Kozak sequence, and coding sequences for the nuclear localization signal of the SV40 large T antigen and for improved Cre recombinase (iCre). Examination of X-gal-stained tissues from male mice bearing both this and the Cre-reporter transgene Gt(ROSA)26tm1Sor demonstrate Cre expression in the testis, epididymis and cremaster muscle of the adult and in the developing testis, epididymis and gubernacular ligaments at embryonic day 14 (E14). RT-PCR analysis of male embryonic tissues confirmed this expression, though only weakly in the vas deferens. Lines 1 and 5 were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:122478)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rxfp2 (species not specified) Summary of all recombinase alleles driven by Rxfp2.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:174719 Li Z, et al., Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2. Endocrinology. 2011 Jun;152(6):2474-82
• All: 2 reference(s)