Pax7^{tm1(cre/ERT2)Gaka}
Targeted Allele Detail

Summary

• Symbol: Pax7^{tm1(cre/ERT2)Gaka}
• Name: paired box 7; targeted mutation 1, Gabrielle Kardon
• MGI ID: MGI:5141477
• Gene: Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
• Alliance: Pax7^{tm1(cre/ERT2)Gaka} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174914
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pax7^{tm1(cre/ERT2)Gaka} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax7 (MGI:97491)

• Mutation details: An IRES-cre/ERT2 and an FRT flanked neomycin selection cassette were inserted 8 bp after the endogenous stop codon. The selection cassette was subsequently removed by crossing to a Gt(ROSA)26Sor^tm1(FLP1)Dym mouse line. Endogenous gene function is preserved. (J:174914)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax7 (mouse) Summary of all recombinase alleles driven by Pax7. Comparative matrix view of recombinase activities Alliance mouse Pax7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax7 Mutation: 38 strains or lines available

References

• Original: J:174914 Murphy MM, et al., Satellite cells, connective tissue fibroblasts and their interactions are crucial for muscle regeneration. Development. 2011 Sep;138(17):3625-37
• All: 99 reference(s)