Cdk6^tm2.1Phin
Targeted Allele Detail

Summary

• Symbol: Cdk6^tm2.1Phin
• Name: cyclin dependent kinase 6; targeted mutation 2.1, Philip Hinds
• MGI ID: MGI:5141514
• Synonyms: Cdk6^R31C
• Gene: Cdk6 Location: Chr5:3391485-3581008 bp, + strand Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
• Alliance: Cdk6^tm2.1Phin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174697
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 1 was replaced with one in which nucleotide substitutions result in the amino acid substitution of cystine for arginine at position 31 (R31C). A floxed stop cassette downstream of the modified exon 1 that prevents expression was removed by cre-mediated recombination. The product is predicted to be a hyperactivate kinase. (J:174697)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdk6 Mutation: 40 strains or lines available

References

• Original: J:174697 Hu MG, et al., CDK6 kinase activity is required for thymocyte development. Blood. 2011 Jun 9;117(23):6120-31
• All: 2 reference(s)