Tg(H2-K1-Ifnb1)10Seif
Transgene Detail

Summary

• Symbol: Tg(H2-K1-Ifnb1)10Seif
• Name: transgene insertion 10, Isabelle Seif
• MGI ID: MGI:5141611
• Synonyms: Tg10, Tg(H2-K1-Ifnb1)10
• Transgene: Tg(H2-K1-Ifnb1)10Seif Location: Chr12:56759419-57286668 bp Genetic Position: Chr12, Syntenic
• Alliance: Tg(H2-K1-Ifnb1)10Seif page

Transgene origin

• Strain of Origin: C3H/HeOuJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K1-Ifnb1)10Seif expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ifnb1 (MGI:107657)

• Mutation details: Random integration of a transgene for IFN beta expressed under the control of a truncated H2-K1 promoter resulted in insertion of the transgene into exon 2 of Prps1l3 and a duplication of the endogenous exon 1 and 2 and exon 1 of Slc25a21 in line 10. (J:174828)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:174828 Satie AP, et al., Excess type I interferon signaling in the mouse seminiferous tubules leads to germ cell loss and sterility. J Biol Chem. 2011 Jul 1;286(26):23280-95
• All: 1 reference(s)