Tg(Vav1-ERG)#Jpim
Transgene Detail

Summary

• Symbol: Tg(Vav1-ERG)#Jpim
• Name: transgene insertion, John E Pimanda
• MGI ID: MGI:5141633
• Synonyms: ERG Tg, vav-ERG3
• Transgene: Tg(Vav1-ERG)#Jpim Location: unknown
• Alliance: Tg(Vav1-ERG)#Jpim page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Vav1-ERG)#Jpim expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERG (2078)

  Erg	(MGI:95415)

  The gene expresses the hematopoietic isoform.

• Mutation details: A 1.4-kb fragment of the human hematopoietic isoform of ERG (ERG3) is under the control fo the Vav1 promoter. Three founders were established. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:174808)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:174808 Thoms JA, et al., ERG promotes T-acute lymphoblastic leukemia and is transcriptionally regulated in leukemic cells by a stem cell enhancer. Blood. 2011 Jun 30;117(26):7079-89
• All: 2 reference(s)