Sos1^tm1.1Les
Targeted Allele Detail

Summary

• Symbol: Sos1^tm1.1Les
• Name: SOS Ras/Rac guanine nucleotide exchange factor 1; targeted mutation 1.1, Lawrence E Samelson
• MGI ID: MGI:5141757
• Gene: Sos1 Location: Chr17:80701181-80787882 bp, - strand Genetic Position: Chr17, 50.67 cM, cytoband C3-D
• Alliance: Sos1^tm1.1Les page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174536
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 10 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 10 via homologous recombination. (J:174536)

Generation of the Sos1^tm1.1Les allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sos1 Mutation: 69 strains or lines available

References

• Original: J:174536 Kortum RL, et al., Targeted Sos1 deletion reveals its critical role in early T-cell development. Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12407-12
• All: 11 reference(s)