Fos^tm4.1Wag
Targeted Allele Detail

Summary

• Symbol: Fos^tm4.1Wag
• Name: FBJ osteosarcoma oncogene; targeted mutation 4.1, Erwin F Wagner
• MGI ID: MGI:5142239
• Synonyms: Fos374A
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm4.1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175064
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified exon in which nucleotide substitutions result in the amino acid substitution of alanine for serine at position 374 (S374A). Flp-mediated recombination removed the floxed neo cassette inserted downstream of the endogenous polyadenylation sequence and left an EGFP gene with a 5' loxP site intact. (J:175064)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Fos^tm4.1Wag/Fos^tm4.1Wag	involves: 129P2/OlaHsd * C57BL/6 * SJL
cx2	Egfr^wa2/Egfr^+ Fos^tm4.1Wag/Fos^tm4.1Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms
immune system	√
decreased interleukin-10 secretion	√
increased interleukin-6 secretion	√
increased tumor necrosis factor secretion	√
increased susceptibility to endotoxin shock	√
integument		√
increased skin papilloma incidence		√
neoplasm		√
increased skin papilloma incidence		√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:175064 Bakiri L, et al., Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene. 2011 Mar 31;30(13):1506-17
• All: 1 reference(s)