Fos^tm5.1Wag
Targeted Allele Detail

Summary

• Symbol: Fos^tm5.1Wag
• Name: FBJ osteosarcoma oncogene; targeted mutation 5.1, Erwin F Wagner
• MGI ID: MGI:5142240
• Synonyms: c-fos^AA, FosAA
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm5.1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175064
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified exon in which nucleotide substitutions result in the amino acid substitution of alanine for serine at positions 362 and 374 (S362A and S374A). Flp-mediated recombination removed the floxed neo cassette inserted downstream of the endogenous polyadenylation sequence and left an EGFP gene with a 5' loxP site intact. (J:175064)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 43 strains or lines available

References

• Original: J:175064 Bakiri L, et al., Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis. Oncogene. 2011 Mar 31;30(13):1506-17
• All: 1 reference(s)