Tg(KRT5-SOS1)892A6Wag
Transgene Detail

Summary

• Symbol: Tg(KRT5-SOS1)892A6Wag
• Name: transgene insertion 892A6, Erwin F Wagner
• MGI ID: MGI:5142254
• Synonyms: K5-SOS-F
• Transgene: Tg(KRT5-SOS1)892A6Wag Location: unknown
• Alliance: Tg(KRT5-SOS1)892A6Wag page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-SOS1)892A6Wag expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SOS1 (6654)

  Sos1	(MGI:98354)

• Tg(KRT5-SOS1)892A6Wag expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: The bovine promoter drives basal keratinocyte-specific expression of an HA tagged dominant form of the human SOS1. Four lines (892A6*, 893A-1, 893B-1, and 893B-2) was generated. Line 892A6 (892A6) contains one or two copies of the transgene. (J:63426)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:63426 Sibilia M, et al., The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell. 2000 Jul 21;102(2):211-20
• All: 8 reference(s)