Mdm4^tm3.1Glo
Targeted Allele Detail

Summary

• Symbol: Mdm4^tm3.1Glo
• Name: transformed mouse 3T3 cell double minute 4; targeted mutation 3.1, Guillermina Lozano
• MGI ID: MGI:5142291
• Synonyms: Mdm4^deltaRING
• Gene: Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
• Alliance: Mdm4^tm3.1Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174368
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 11, and a floxed neo cassette and mutant version of exon 11 (with an in frame deletion of the 49 RING domain encoding amino acids) were inserted downstream of exon 11 via homologous recombination. Cre mediated recombination removed the endogenous exon 11 and the neo cassette, leaving the modified exon 11 in place. (J:174368)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mdm4 Mutation: 193 strains or lines available

References

• Original: J:174368 Pant V, et al., Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):11995-2000
• All: 1 reference(s)