Pappa2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Pappa2^tm1Lex
• Name: pappalysin 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:5142320
• Gene: Pappa2 Location: Chr1:158539297-158788019 bp, - strand Genetic Position: Chr1, 68.49 cM
• Alliance: Pappa2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174887
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment including exons 4 and 5 was replaced with a beta galactosidase neomycin fusion marker and a pgk-puro marker via homologous recombination. PCR analysis confirmed the absence of expression in multiple tissues from homozygous mice. (J:174887)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pappa2 Mutation: 88 strains or lines available

References

• Original: J:174887 Conover CA, et al., Pregnancy-associated plasma protein-A2 (PAPP-A2): tissue expression and biological consequences of gene knockout in mice. Endocrinology. 2011 Jul;152(7):2837-44
• All: 1 reference(s)