Pink1^tm1Hlw
Targeted Allele Detail

Summary

• Symbol: Pink1^tm1Hlw
• Name: PTEN induced putative kinase 1; targeted mutation 1, Hung-Li Wang
• MGI ID: MGI:5142502
• Gene: Pink1 Location: Chr4:138040720-138053618 bp, - strand Genetic Position: Chr4, 70.14 cM
• Alliance: Pink1^tm1Hlw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of transcript expression was confirmed by northern blot analysis. (J:175006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pink1 Mutation: 43 strains or lines available

References

• Original: J:175006 Wang HL, et al., PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochim Biophys Acta. 2011 Jun;1812(6):674-84
• All: 2 reference(s)