Nras^tm1Zhng
Targeted Allele Detail

Summary

• Symbol: Nras^tm1Zhng
• Name: neuroblastoma ras oncogene; targeted mutation 1, Jing Zhang
• MGI ID: MGI:5142507
• Synonyms: LSL Nras G12D^hypo
• Gene: Nras Location: Chr3:102965643-102975230 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Nras^tm1Zhng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174880
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A Glycine to Aspartic acid coding change at codon 12 was created and a loxP-stop-loxP site was inserted in intron 1. (J:174880)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nras Mutation: 44 strains or lines available

References

• Original: J:174880 Wang J, et al., Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood. 2011 Jul 14;118(2):368-79
• All: 1 reference(s)