Slco1a1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Slco1a1^tm1Dgen
• Name: solute carrier organic anion transporter family, member 1a1; targeted mutation 1, Deltagen
• MGI ID: MGI:5142510
• Gene: Slco1a1 Location: Chr6:141853008-141892688 bp, - strand Genetic Position: Chr6, 73.09 cM, cytoband A3-A5
• Alliance: Slco1a1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174999
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with an IRES-lacZ reporter and neo cassette. The absence of protein expression was confirmed by western blot analysis on liver extracts. (J:174999)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slco1a1 Mutation: 40 strains or lines available

References

• Original: J:174999 Gong L, et al., Characterization of organic anion-transporting polypeptide (oatp) 1a1 and 1a4 null mice reveals altered transport function and urinary metabolomic profiles. Toxicol Sci. 2011 Aug;122(2):587-97
• All: 4 reference(s)