Fcmr^tm1.2Khl
Targeted Allele Detail

Summary

• Symbol: Fcmr^tm1.2Khl
• Name: Fc fragment of IgM receptor; targeted mutation 1.2, Kyeong-Hee Lee
• MGI ID: MGI:5142529
• Synonyms: Toso^ko
• Gene: Fcmr Location: Chr1:130793514-130808528 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband E4
• Alliance: Fcmr^tm1.2Khl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174871
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed exons 4 through 7. Flow cytrometry confirmed the absence of protein expression. (J:174871)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcmr Mutation: 28 strains or lines available

References

• Original: J:174871 Nguyen XH, et al., Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination. Blood. 2011 Jul 21;118(3):598-608
• All: 4 reference(s)