Arhgef2^{Gt(IST13976A8)Tigm}
Gene trapped Allele Detail

Summary

• Symbol: Arhgef2^{Gt(IST13976A8)Tigm}
• Name: Rho/Rac guanine nucleotide exchange factor 2; gene trap IST13976A8, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5200558
• Synonyms: Arhgef2 ^tm1Hcr
• Gene: Arhgef2 Location: Chr3:88513273-88555359 bp, + strand Genetic Position: Chr3, 38.9 cM, cytoband F1
• Alliance: Arhgef2^{Gt(IST13976A8)Tigm} page

Mutation origin

• Mutant Cell Line: IST13976A8
• Germline Transmission: Earliest citation of germline transmission: J:209086
• Parent Cell Line: Lex3.13 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted between exon 4 and 5. Western blot analysis confirmed the absence of protein expression in macrophages. (J:209086)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  IST13976A8HMF1	JM270087 ; (MGI Seq Detail)	inverse PCR	Chr3:88531756-88532168 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  31 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	31 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 1 line available
• Carrying any Arhgef2 Mutation: 75 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 6 reference(s)