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Etv6tm1.1(RUNX1,hsb5)Lvdw
Targeted Allele Detail
Summary
Symbol: Etv6tm1.1(RUNX1,hsb5)Lvdw
Name: ets variant 6; targeted mutation 1.1, Louise van der Weyden
MGI ID: MGI:5284820
Synonyms: Etv6RUNX1
Gene: Etv6  Location: Chr6:134012663-134247121 bp, + strand  Genetic Position: Chr6, 64.58 cM, cytoband G2
Alliance: Etv6tm1.1(RUNX1,hsb5)Lvdw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174866
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsA construct, which contains a lox66, exons 1 through 6 of human RUNX1 (hAML1), IRES, hyperactive variant of sleeping beauty (hsb5), polyadenylation sequence, FRT-flanked puro cassette, and lox71 site, was inserted into intron 5. Mice express a Etv6/RUNX1 fusion to replicate the TEL-AML1 translocation associated with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and hsb5. Flp-mediated recombination removed the puro cassette. Embryonic lethality indicates that no functional endogenous protein is produced despite the production of the endogenous transcript. (J:174866)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv6 Mutation:  144 strains or lines available
References
Original:  J:174866 van der Weyden L, et al., Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice. Blood. 2011 Jul 28;118(4):1041-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory