Stat1^tm1Uvin
Targeted Allele Detail

Summary

• Symbol: Stat1^tm1Uvin
• Name: signal transducer and activator of transcription 1; targeted mutation 1, Uwe Vinkemeier
• MGI ID: MGI:5284857
• Synonyms: STAT1-deltaSUMO, STAT1-Glu705Gln
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^tm1Uvin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174863
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Nucleotide substitution(s) results in the amino acid substitution of glutamine for glutamic acid at position 705 (E705Q) that abolishes SUMO conjugation. (J:174863)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 74 strains or lines available

References

• Original: J:174863 Begitt A, et al., SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN{gamma}. Blood. 2011 Jul 28;118(4):1002-7
• All: 1 reference(s)