Sema5b^tm1.2Alk
Targeted Allele Detail

Summary

• Symbol: Sema5b^tm1.2Alk
• Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B; targeted mutation 1.2, Alex L Kolodkin
• MGI ID: MGI:5284883
• Synonyms: Sema5B^-
• Gene: Sema5b Location: Chr16:35361517-35485103 bp, + strand Genetic Position: Chr16, 25.37 cM
• Alliance: Sema5b^tm1.2Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2, and a frt-flanked neomycin resistance (neo) cassette followed by a second loxP site just downstream of exon 2 of the semaphorin 5B (Sema5b) targeted gene. Cre-mediated recombination removed exon 2 and the neo cassette. (J:174679)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sema5b Mutation: 80 strains or lines available

References

• Original: J:174679 Matsuoka RL, et al., Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Neuron. 2011 Aug 11;71(3):460-73
• All: 4 reference(s)