Khsrp^tm1.1Cyc
Targeted Allele Detail

Summary

• Symbol: Khsrp^tm1.1Cyc
• Name: KH-type splicing regulatory protein; targeted mutation 1.1, Ching-Yi Chen
• MGI ID: MGI:5285092
• Gene: Khsrp Location: Chr17:57328049-57338507 bp, - strand Genetic Position: Chr17, 29.63 cM
• Alliance: Khsrp^tm1.1Cyc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175084
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 13 were replaced with a floxed hygro cassette. Cre-mediated recombination removed the hygro cassette. Northern blot analysis confirmed the absence of transcript expression. (J:175084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Khsrp Mutation: 35 strains or lines available

References

• Original: J:175084 Lin WJ, et al., Posttranscriptional Control of Type I Interferon Genes by KSRP in the Innate Immune Response against Viral Infection. Mol Cell Biol. 2011 Aug;31(16):3196-207
• All: 11 reference(s)