Tdg^tm1.1Abc
Targeted Allele Detail

Summary

• Symbol: Tdg^tm1.1Abc
• Name: thymine DNA glycosylase; targeted mutation 1.1, Alfonso Bellacosa
• MGI ID: MGI:5285105
• Gene: Tdg Location: Chr10:82465662-82486633 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tdg^tm1.1Abc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174772
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neo cassette with a loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 3 through 7. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:174772)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tdg^tm1.1Abc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdg Mutation: 23 strains or lines available

References

• Original: J:174772 Cortellino S, et al., Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell. 2011 Jul 8;146(1):67-79
• All: 2 reference(s)