Tg(Thy1-HSPB1*S135F)#Lvdb
Transgene Detail

Summary

• Symbol: Tg(Thy1-HSPB1*S135F)#Lvdb
• Name: transgene insertion, Ludo Van Den Bosch
• MGI ID: MGI:5285200
• Synonyms: HSPB1^S135F, S135F
• Transgene: Tg(Thy1-HSPB1*S135F)#Lvdb Location: unknown
• Alliance: Tg(Thy1-HSPB1*S135F)#Lvdb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-HSPB1*S135F)#Lvdb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HSPB1 (3315)

  Hspb1

  (MGI:96240)

• Mutation details: The transgene construct contains the human HSPB1 cDNA harboring the S135F mutation coupled to an N-terminal hemagglutinin (HA) tag driven by the murine Thy1.2 expression cassette. The transgene is expressed in the gray matter and in extended processes in the white matter. A # is used to indicate that a line number was not provided in the original publication. (J:174508)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:174508 d'Ydewalle C, et al., HDAC6 inhibitors reverse axonal loss in a mouse model of mutant HSPB1-induced Charcot-Marie-Tooth disease. Nat Med. 2011;17(8):968-74
• All: 1 reference(s)