Bsnd^tm1.1Suc
Targeted Allele Detail

Summary

• Symbol: Bsnd^tm1.1Suc
• Name: barttin CLCNK type accessory beta subunit; targeted mutation 1.1, Shinichi Uchida
• MGI ID: MGI:5285211
• Synonyms: Bsnd^R8L
• Gene: Bsnd Location: Chr4:106340653-106349440 bp, - strand Genetic Position: Chr4, 49.67 cM
• Alliance: Bsnd^tm1.1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175265
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Humanized sequence, Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Cre-mediated recombination removed the neo cassette downstream of the modified exon 1 with the R8L substitution (mimicking a mutation found in some Bartter syndrome patients) and removed by cre-mediated recombination. (J:175265)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bsnd Mutation: 16 strains or lines available

References

• Original: J:175265 Nomura N, et al., Generation and analyses of R8L barttin knockin mouse. Am J Physiol Renal Physiol. 2011 Aug;301(2):F297-307
• All: 3 reference(s)