Oas1b^tm1.1Brin
Targeted Allele Detail

Summary

• Symbol: Oas1b^tm1.1Brin
• Name: 2'-5' oligoadenylate synthetase 1B; targeted mutation 1.1, Margo A Brinton
• MGI ID: MGI:5285411
• Synonyms: Oas1b^r
• Gene: Oas1b Location: Chr5:120950700-120962228 bp, + strand Genetic Position: Chr5, 60.64 cM, cytoband F
• Alliance: Oas1b^tm1.1Brin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175365
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exons 4 was replaced with a modified exon 4 in which nucleotide substitutions (T to C and A to G) result in the amino acid substitutions of arginine for a premature stop codon and glutamine at positions 253 and 266 (Stop 253R and Q266R). Exon 5 was replaced with a modified exon 5 in which nucleotide substitutions (A to G and T to C) result in the amino acid substitutions of alanine and proline for threonine and serine at positions 299 and 336 (T299A and S336P). A floxed neo cassette inserted downstream of the modified exon 4 was removed by cre-mediated recombination. (J:175365)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oas1b Mutation: 15 strains or lines available

References

• Original: J:175365 Scherbik SV, et al., Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype. Virology. 2007 Nov 25;368(2):232-7
• All: 3 reference(s)