Tet2^tm1.2Rao
Targeted Allele Detail

Summary

• Symbol: Tet2^tm1.2Rao
• Name: tet methylcytosine dioxygenase 2; targeted mutation 1.2, Anjana Rao
• MGI ID: MGI:5285413
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm1.2Rao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175222
• Parent Cell Line: ART B6-3, B6-3 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 8 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 10 via homologous recombination. Recombinase mediated recombination removed exons 8 - 10 and the neo cassette. (J:175222)

Targeting strategy to generate the Tet2^tm1.1Rao and Tet2^tm1.2Rao alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 779 strains or lines available

References

• Original: J:175222 Ko M, et al., Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14566-71
• All: 38 reference(s)