Adamts5^tm2.2Lex
Targeted Allele Detail

Summary

• Symbol: Adamts5^tm2.2Lex
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 5; targeted mutation 2.2, Lexicon Genetics
• MGI ID: MGI:5285450
• Synonyms: ts5^-
• Gene: Adamts5 Location: Chr16:85655045-85698013 bp, - strand Genetic Position: Chr16, 48.34 cM
• Alliance: Adamts5^tm2.2Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:175366
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2, which encodes part of the zinc binding domain. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neo cassette. Cre-mediated recombination removed the neo cassette. (J:175366)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts5 Mutation: 56 strains or lines available

References

• Original: J:175366 Malfait AM, et al., ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization. Osteoarthritis Cartilage. 2010 Apr;18(4):572-80
• All: 6 reference(s)