Tg(BEST1-HTRA1)#Ybf
Transgene Detail

Summary

• Symbol: Tg(BEST1-HTRA1)#Ybf
• Name: transgene insertion, Yingbin Fu
• MGI ID: MGI:5285549
• Synonyms: hHTRA1+
• Transgene: Tg(BEST1-HTRA1)#Ybf Location: unknown
• Alliance: Tg(BEST1-HTRA1)#Ybf page

Tg(BEST1-HTRA1)#Ybf/0 mice develop polypoidal choroidal vasculopathy

Show the 6 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(BEST1-HTRA1)#Ybf expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HTRA1 (5654)

  Htra1

  (MGI:1929076)

• Mutation details: A 1.5-kb human HTRA1 cDNA was placed under the control of the human VMD2 promoter(585 to +38 bp) and CMV enhancer/promoter. (J:175227, J:201036)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Polypoidal Choroidal Vasculopathy J:175227

References

• Original: J:175227 Jones A, et al., Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14578-83
• All: 2 reference(s)