Camk2b^tm2.1Yelg
Targeted Allele Detail

Summary

• Symbol: Camk2b^tm2.1Yelg
• Name: calcium/calmodulin-dependent protein kinase II, beta; targeted mutation 2.1, Ype Elgersma
• MGI ID: MGI:5285573
• Synonyms: Camk2b^A303R
• Gene: Camk2b Location: Chr11:5919644-6016362 bp, - strand Genetic Position: Chr11, 3.89 cM
• Alliance: Camk2b^tm2.1Yelg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174521
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 12 was replaced with a modified exon 12 in which nucleotide substitutions (GCC ATC to AGA ATT) results in the amino acid substitution of arginine for alanine at position 303 (A303R). A floxed neo cassette inserted upstream of the modified exon 12 was removed by cre-mediated recombination. (J:174521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Camk2b Mutation: 92 strains or lines available

References

• Original: J:174521 Borgesius NZ, et al., betaCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting alphaCaMKII to synapses. J Neurosci. 2011 Jul 13;31(28):10141-8
• All: 4 reference(s)