Chrna4^tm1.2Tmcg
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1.2Tmcg
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1.2, Tresa M McGranahan
• MGI ID: MGI:5285619
• Synonyms: alpha4 -
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1.2Tmcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174505
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 5 and the neo cassette. In situ hybridization confirmed the absence of transcript expression in brain samples. (J:174505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 44 strains or lines available

References

• Original: J:174505 McGranahan TM, et al., alpha4beta2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci. 2011 Jul 27;31(30):10891-902
• All: 1 reference(s)