Tgfbr1^R244Q
Chemically induced Allele Detail

Summary

• Symbol: Tgfbr1^R244Q
• Name: transforming growth factor, beta receptor I; Arg244Gln
• MGI ID: MGI:5285662
• Synonyms: R244Q
• Gene: Tgfbr1 Location: Chr4:47353258-47414926 bp, + strand Genetic Position: Chr4, 26.02 cM
• Alliance: Tgfbr1^R244Q page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An ENU induced G to A mutation is located at position 731 resulting in an arginine to glutamine substitution at position 244. This substitution results in partial activation of the receptor. (J:79725, J:175236)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgfbr1 Mutation: 36 strains or lines available

References

• Original: J:175236 Liu J, et al., Regenerative phenotype in mice with a point mutation in transforming growth factor {beta} type I receptor (TGFBR1). Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14560-5
• All: 2 reference(s)