Lmnb2^tm1.1Sgy
Targeted Allele Detail

Summary

• Symbol: Lmnb2^tm1.1Sgy
• Name: lamin B2; targeted mutation 1.1, Stephen G Young
• MGI ID: MGI:5285673
• Synonyms: Lmnb2^fl
• Gene: Lmnb2 Location: Chr10:80737197-80754079 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C
• Alliance: Lmnb2^tm1.1Sgy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174963
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked beta-geo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the reporter cassette. (J:174963)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmnb2 Mutation: 27 strains or lines available

References

• Original: J:174963 Yang SH, et al., An absence of both lamin B1 and lamin B2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. Hum Mol Genet. 2011 Sep 15;20(18):3537-44
• All: 6 reference(s)