Lgr5^tm2.1Cle
Targeted Allele Detail

Summary

• Symbol: Lgr5^tm2.1Cle
• Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 2.1, Hans Clevers
• MGI ID: MGI:5285688
• Synonyms: Lgr5fl, Lgr5-Flox exon16
• Gene: Lgr5 Location: Chr10:115286219-115423685 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Lgr5^tm2.1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 16. A floxed neo cassette was inserted downstream of exon 16. Cre-mediated recombination removed the neo cassette and left exon 16 floxed. (J:174842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr5 Mutation: 58 strains or lines available

References

• Original: J:174842 de Lau W, et al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Aug 18;476(7360):293-7
• All: 4 reference(s)