Lgr4^{tm1(cre/ERT2)Cle}
Targeted Allele Detail

Summary

• Symbol: Lgr4^{tm1(cre/ERT2)Cle}
• Name: leucine-rich repeat-containing G protein-coupled receptor 4; targeted mutation 1, Hans Clevers
• MGI ID: MGI:5285689
• Synonyms: Lgr4^{GFP-ires-CreERT2}
• Gene: Lgr4 Location: Chr2:109747992-109844602 bp, + strand Genetic Position: Chr2, 56.65 cM
• Alliance: Lgr4^{tm1(cre/ERT2)Cle} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174842
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Lgr4^{tm1(cre/ERT2)Cle} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lgr4 (MGI:1891468)

• A GFP, ires, cre/ERT2 fusion were inserted downstream of the translation initiation site. (J:174842)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lgr4 (mouse) Summary of all recombinase alleles driven by Lgr4. Comparative matrix view of recombinase activities Alliance mouse Lgr4 gene page

Expression

In Mice Carrying this Mutation:

43 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgr4 Mutation: 94 strains or lines available

References

• Original: J:174842 de Lau W, et al., Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling. Nature. 2011 Aug 18;476(7360):293-7
• All: 5 reference(s)