Nrg1^m1Yzcm
Chemically induced Allele Detail

Summary

• Symbol: Nrg1^m1Yzcm
• Name: neuregulin 1; mutation 1, Yangzhou University Comparative Medicine Center
• MGI ID: MGI:5285952
• Synonyms: Nrg1^Dp1
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^m1Yzcm page

Dilated pupils in Nrg1^m1Yzcm/Nrg1⁺ and Nrg1^m1Yzcm/Nrg1^m1Yzcm mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transition in the 5' splice donor site downstream of exon 59. RT-PCR confirmed the expression of multiple transcripts of different lengths. (J:175524)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 54 strains or lines available

References

• Original: J:175524 Chen B, et al., An ENU-induced mutation of Nrg1 causes dilated pupils and a reduction in muscarinic receptors in the sphincter pupillae. PLoS One. 2011;6(9):e25176
• All: 1 reference(s)