Akap12^tm1Ihg
Targeted Allele Detail

Summary

• Symbol: Akap12^tm1Ihg
• Name: A kinase anchor protein 12; targeted mutation 1, Irwin H Gelman
• MGI ID: MGI:5286076
• Synonyms: mSSeCKS^-
• Gene: Akap12 Location: Chr10:4216380-4309470 bp, + strand Genetic Position: Chr10, 2.06 cM
• Alliance: Akap12^tm1Ihg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138882
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A lacZ followed by a neomycin selection cassette were inserted in exon2. Western blot analysis demonstrated the absence of all three major isoforms (alpha, beta, gamma). (J:138882)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Akap12^tm1Ihg

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akap12 Mutation: 215 strains or lines available

References

• Original: J:138882 Akakura S, et al., Loss of the SSeCKS/Gravin/AKAP12 gene results in prostatic hyperplasia. Cancer Res. 2008 Jul 1;68(13):5096-103
• All: 10 reference(s)