Tg(tetO-SMN2,-luc)#aAhmb
Transgene Detail

Summary

• Symbol: Tg(tetO-SMN2,-luc)#aAhmb
• Name: transgene insertion, Arthur H M Burghes
• MGI ID: MGI:5286602
• Synonyms: Luci-TRE-SMN
• Transgene: Tg(tetO-SMN2,-luc)#aAhmb Location: unknown
• Alliance: Tg(tetO-SMN2,-luc)#aAhmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-SMN2,-luc)#aAhmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SMN2 (6607)

  Smn1	(MGI:109257)

• Mutation details: The tetracycline response element with two minimal CMV promoters drives inducible expression of human SMN (exons 1 through 7) and a luciferase gene. Two lines were generated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:174960)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:174960 Le TT, et al., Temporal requirement for high SMN expression in SMA mice. Hum Mol Genet. 2011 Sep 15;20(18):3578-91
• All: 1 reference(s)